Latrunculin A Delays Anaphase Onset in Fission Yeast by Disrupting an Ase1-independent Pathway Controlling Mitotic Spindle Stability
نویسندگان
چکیده
منابع مشابه
Latrunculin A delays anaphase onset in fission yeast by disrupting an Ase1-independent pathway controlling mitotic spindle stability.
It has been proposed previously that latrunculin A, an inhibitor of actin polymerization, delays the onset of anaphase by causing spindle misorientation in fission yeast. However, we show that Delta mto1 cells, which are defective in nucleation of cytoplasmic microtubules, have profoundly misoriented spindles but are not delayed in the timing of sister chromatid separation, providing compelling...
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It has previously been proposed that in fission yeast mitotic spindle position is monitored by a checkpoint that controls the timing of anaphase onset. This checkpoint is activated by treatment of cells with Latrunculin A (Lat A), an inhibitor of actin polymerisation. It was previously thought that Lat A imposes an anaphase delay by preventing interaction of astral microtubules with the cortica...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2008
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e08-02-0164